This animation may only be used in support of a single legal proceeding and for no other purpose. Read our License Agreement for details. To license this image for other purposes, click here.
MEDICAL ANIMATION TRANSCRIPT: The brain's cognitive functions include memory, which is the process of information retention and retrieval. Memories form in the hippocampus, which consists of information-processing cells called neurons. Each neuron receives chemical messages from other neurons via dendrites, then converts the message to an electrical charge called an action potential. In the space between them, neurons release stimulatory chemicals called neurotransmitters, which bind with receptors on the receiving cell and transfer information. Alzheimer's disease is a gradual, degenerative brain condition in which neurons in the memory and other cognitive areas of the brain lose function and die, resulting in progressive memory loss first, then difficulties learning and communicating, and, eventually, failing basic functions like breathing. In healthy neurons, enzymes help process a protein called amyloid precursor protein into fragments which help with normal cell function. In Alzheimer's, abnormal enzymatic processing produces fragments that include a sticky peptide called beta amyloid. Beta amyloid accumulates in the extracellular space, forming clumps called amyloid plaques. These clumps block the electrical and chemical connections between neurons. Inside healthy neurons, microtubules and tau proteins form an orderly structure that carries ions and nutrients within the cell. In Alzheimer's, chemical changes inside the neurons damage tau, twisting microtubules abnormally into neurofibrillary tangles, which disrupts ion and nutrient delivery within the cell. As the plaques and tangles multiply throughout brain tissue, neural connections diminish, and the malnourished cells lose function, resulting in widespread neural death, reduced brain mass, and severe cognitive and functional impairment. There is no cure for Alzheimer's, but current treatments include cholinesterase inhibitors, which delay the breakdown of acetylcholine, a neurotransmitter important for memory and learning, and antiglutamatergic medications, which regulate the activity of glutamate, another neurotransmitter essential for memory and learning, by blocking excessive glutamate binding to neurons, thus preventing neuronal dysfunction and death. ♪ [music] ♪
"The illustrations have consistently been well documented, accurate and
timely. Most important though is that the illustrations demonstrate to
juries and claims people the persuasive power of visual communication. Our
firm has achieved multiple eight figure settlements and verdicts over the
past ten years... Medical Legal Art has been there with us on every case."
Thomas C. Jones
Davis, Bethune & Jones, L.L.C.
Kansas City, MO www.dbjlaw.net
"This past year, your company prepared three medical illustrations for our cases; two in which we received six figure awards; one in which we received a substantial seven figure award. I believe in large part, the amounts obtained were due to the vivid illustrations of my clients' injuries and the impact on the finder of fact."
Donald W. Marcari
Marcari Russotto & Spencer, P.C.
Chesapeake, VA
"I just wanted to let you know that after several days on trial, I settled
[my client's] construction accident case for $4.5 million. Immediately after
the jury was discharged, I spoke with several jurors who told me that they
really appreciated the medical illustrations for their clarity in dealing
with [my client's] devastating injuries. They also expressed their gratitude
in being able to read from a distance all of the notations without
difficulty. Obviously, the boards were visually persuasive. I am certain
that this contributed to our successful result."
Michael Gunzburg, Esq.
Attorney at Law.
New York, NY
"For us, the defining feature of effective demonstrative evidence is
whether, by itself, the piece will tell the story of the case. Medical legal
Art provides our firm with illustrations and animations that are clear and
persuasive. Their exhibits tell the story in a way that allows the jury to
understand a very complex subject, very quickly."
James D. Horwitz Koskoff, Koskoff & Bieder, P.C. Bridgeport, CT
Medical Legal Art creates medical demonstrative evidence (medical
illustrations, drawings, pictures, graphics, charts, medical animations,
anatomical models, and interactive presentations) for use during legal
proceedings, including research, demand letters, client conferences,
depositions, arbitrations, mediations, settlement conferences, mock jury
trials and for use in the courtroom. We do not provide legal or medical
advice. If you have legal questions, you should find a lawyer with whom you
can discuss your case issues. If you have medical questions, you should seek the advice of a healthcare provider.
