This animation may only be used in support of a single legal proceeding and for no other purpose. Read our License Agreement for details. To license this image for other purposes, click here.
|Inflammation - Medical Animation
|MEDICAL ANIMATION TRANSCRIPT: Inflammation is a local immune response to tissue injury or infection, experienced as heat, redness, edema, pain, and loss of function. Immediately after injury, inflammation begins with brief vasoconstriction of the local blood vessels to reduce blood loss and formation of a clot to stop the bleeding. Then, stimulated by cell injury and death, local cells release vasoactive chemicals, such as prostaglandins and histamine to dilate local blood vessels leading to increased blood flow to the area. These chemicals also cause endothelial cells in small blood vessels to contract, opening spaces between them. This increased capillary permeability allows fluids and proteins to pass from the blood into the tissue. Next, during a multi-stage process called chemotaxis, circulating immune cells called neutrophils move out of the blood vessels to the site of injury and destroy pathogens and damaged cells. Chemotaxis begins when cells at the injury site release messenger molecules called chemoattractants, which cause local endothelial cells and circulating neutrophils to stick together. Next, in a process called diapedesis, neutrophils squeeze through the endothelial gaps. The neutrophils migrate to the injury site by following a chemotactic gradient. Upon arrival, the neutrophils encounter bacteria, engulf them and digest them in a process called phagocytosis. After destruction of the bacteria and removal of cellular waste, tissue repair begins when locally produced growth factors cause local fibroblasts to begin dividing rapidly and secreting large quantities of collagen to reinforce the wound. Anti-inflammatory drugs inhibit inflammation by blocking production of inflammatory chemicals. The most common drugs for inflammation are non-steroidal anti-inflammatory drugs, or NSAIDS, such as aspirin and ibuprofen. They contain an enzyme called cyclooxygenase or COX, that inhibits the production of prostaglandins and several other inflammatory chemicals. Thus, reducing vasodilation, edema, and pain associated with inflammation. ♪ [music] ♪|
|What attorneys say about MLA and The Doe Report:
|"It is with great enthusiasm that I recommend Medical Legal Art. We have
used their services for three years and always found their professionalism,
quality of work, and timely attention to detail to exceed our expectations.
We recently settled two complicated catastrophic injury cases. One medical
malpractice case involving a spinal abscess settled for 3.75 million and the
other involving injuries related to a motor vehicle accident settled for 6.9
million. We consider the artwork provided by MLA to have been invaluable in
helping us to successfully conclude these cases.
I highly recommend MLA to anyone seeking high quality, detailed medical
E. Marcus Davis, Esq.
Davis Zipperman, Krischenbaum & Lotito
|"I wanted to thank you for the terrific job you did illustrating my client's
injuries. The case was settled at the pre-suit mediation, and I believe a
good part of the success we had was due to the medical legal art you
Your work received the ultimate compliment at the conclusion of the mediation. The hospital risk manager took the exhibit with them at the
conclusion of mediation, and will be using it to train nurses on how to
prevent bed sores..."
Steven G. Koeppel
Troy, Yeslow & Koeppel, P.A.
Fort Myers, FL
|"Our firm was able to settle our case at an all day mediation yesterday and
I am confident that the detail and overall appearance of the medical
illustrations significantly contributed to the settlement. When we require
medical illustrations in the future, I will be sure to contact [MLA]."
Noel Turner, III
Burts, Turner, Rhodes & Thompson
|"Whether it's demonstrating a rotator cuff tear, neck movement a few
milliseconds after rear impact, or a proposed lumbar fusion, the Doe Report
represents an instant on-line database of medical illustration for
health-care and legal professionals.
Illustrations can be purchased 'as is' or modified within hours and sent
either electronically or mounted on posterboard. An illustration is worth a
thousand words, as juries perk up and look intently to capture concepts
that are otherwise too abstract. Start with good illustrations, a clear and
direct voice, a view of the jury as 12 medical students on day one of
training, and your expert testimony becomes a pleasure, even on cross
examination. An experienced trial lawyer should also emphasize these
illustrations at the end of trial, as a means of visually reinforcing key
As a treating physician, I also use these accurate illustrations to educate
my own patients about their medical conditions. The Doe Report is an
invaluable resource, and its authors at MLA have always been a pleasure to
Richard E. Seroussi M.D., M.Sc.
Diplomate, American Boards of Electrodiagnostic Medicine and PM&R
Seattle Spine & Rehabilitation Medicine