Follow us On YouTube Follow us On FaceBook



or
Search Language
Browse
Medical Animations
Medical Animation Titles
Custom Legal Animations
Patient Health Articles
Most Recent Uploads
Body Systems/Regions
Anatomy & Physiology
Diseases & Conditions
Diagnostics & Surgery
Cells & Tissues
Cardiovascular System
Digestive System
Integumentary System
Nervous System
Reproductive System
Respiratory System
Back and Spine
Foot and Ankle
Head and Neck
Hip
Knee
Shoulder
Thorax
Medical Specialties
Cancer
Cardiology
Dentistry
Editorial
Neurology/Neurosurgery
Ob/Gyn
Orthopedics
Pediatrics
Account
Administrator Login

Medication Absorption - Medical Animation

 

This animation may only be used in support of a single legal proceeding and for no other purpose. Read our License Agreement for details. To license this image for other purposes, click here.

Ready to License?

Item #ANM11011 — Source #1

Order by phone: (800) 338-5954

Medication Absorption - Medical Animation
MEDICAL ANIMATION TRANSCRIPT: Medication absorption is the movement of a drug from its site of administration into the blood. Oral drugs enter the stomach where they either dissolve and pass through the cell membranes of epithelial cells lining the stomach or travel undissolved through the stomach to the small intestine, which is the most common site of absorption. Here, drugs dissolve and pass through the intestinal wall. Oral drugs then travel through the portal venous system to the liver, where they undergo the first pass effect. During this process, the liver metabolizes some of the drug, either inactivating it or excreting it into bile for elimination from the body. The remaining amount of active drug leaves the liver and reaches general circulation and target organs. If a drug is administered via intravenous injection, it passes directly into the bloodstream, thus bypassing absorption in the GI tract. If administered through intramuscular or subcutaneous injection, the drug enters either muscle or subcutaneous tissue, where it passes through gaps between cells into capillary walls and then into general circulation or target organs, also bypassing absorption in the GI tract. Bioavailability is the net amount of a dose of a drug that is actually absorbed into the bloodstream. The bioavailability of oral drugs is less than 100% because of the first pass effect of the liver. In contrast, the bioavailability of IV drugs is 100% because they are not exposed to the first pass effect of the liver. Different drug formulations alter bioavailability, because they are not absorbed at the same rate or to the same extent. For example, tablets dissolve at varying rates. Enteric coated drugs dissolve in the small intestine, not the stomach. Because gastric emptying time differs between individuals, absorption times also vary. Sustained release formulas contain tiny spheres that dissolve at different rates, resulting in a steady drug release throughout the day, but also resulting in variable absorption. Some factors affecting drug absorption are the rate of dissolution. Drugs that dissolve faster are absorbed faster. Surface area, since the lining of the small intestine has more surface area than the lining of the stomach, most drugs are absorbed faster in the small intestine. Blood flow, the greater the concentration gradient between the drug-filled stomach and the rapidly flowing drug-free blood, the faster the absorption. Lipid solubility, highly lipid soluble drugs pass through the phospholipids in the cell membrane more easily than drugs of low lipid solubility. And PH partitioning, absorption is faster when the difference between the PH at the site of administration and the PH of the plasma attracts more drug molecules to ionize in the plasma. ♪ [music] ♪

YOU MAY ALSO WANT TO REVIEW THESE ITEMS:
Anatomy of a Neuron (Nerve Cell)
Anatomy of a Neuron (Nerve Cell) - ANS00035
Medical Animation
Add to my lightbox
Find More Like This
Medication Distribution
Medication Distribution - ANM10008
Medical Animation
Add to my lightbox
Find More Like This
Anatomy and Physiology of the Brain
Anatomy and Physiology of the Brain - ANS12530
Medical Animation
Add to my lightbox
Find More Like This
Stem Cell Research - Organs
Stem Cell Research - Organs - AU00030
Medical Illustration
Add to my lightbox
Find More Like This
Anatomy and Physiology of the Kidney
Anatomy and Physiology of the Kidney - exh4866a
Medical Exhibit
Add to my lightbox
Find More Like This
Cell
Cell - ANM11024
Medical Animation
Add to my lightbox
Find More Like This
What attorneys say about MLA and The Doe Report:
"We got a defense verdict yesterday! Your exhibit was extremely helpful in showing the jury how unlikely it is to damage all four of the nerve branches which control the sense of taste."

Karen M. Talbot
Silverman Bernheim & Vogel, P.C.
Philadeplphia, PA

"Medical Legal Art wins our firm's highest accolades for professionalism and exhibit quality. In fact, many of the doctors I work with request color copies of your outstanding artwork to show to patients during the informed consent process."

Jeanne Dolan, BSRN, AlNC
Legal Nurse Consultant
Golden Valley, MN

"I have a medical illustration created by Medical Legal Art at the beginning of every case to tell the client's story, usually before I depose the defendant doctor. The work product and cost-efficiency are outstanding. It is a situation where, as a trial lawyer, I don't leave home without it."

Rockne Onstad
Attorney at Law
Austin, TX

"[I] have come to rely upon the Doe Report and your great staff of illustrators for all my medical malpractice cases. … Please know that I enthusiastically recommend you to all my colleagues.

Frank Rothermel
Bernhardt & Rothermel












Awards | Resources | Articles | Become an Affiliate | Free Medical Images | Pregnancy Videos
Credits | Jobs | Help | Medical Legal Blog | Find a Lawyer | Hospital Marketing