Quantcast
Follow us On YouTube Follow us On FaceBook



or
Search Language
Browse
Medical Animations
Medical Animation Titles
Custom Legal Animations
Patient Health Articles
Custom Interactive
Most Recent Uploads
Body Systems/Regions
Anatomy & Physiology
Diseases & Conditions
Diagnostics & Surgery
Cells & Tissues
Cardiovascular System
Digestive System
Integumentary System
Nervous System
Reproductive System
Respiratory System
Back and Spine
Foot and Ankle
Head and Neck
Hip
Knee
Shoulder
Thorax
Medical Specialties
Cancer
Cardiology
Dentistry
Editorial
Neurology/Neurosurgery
Ob/Gyn
Orthopedics
Pediatrics
Account
Administrator Login
Medication Distribution - Medical Animation
 
This animation may only be used in support of a single legal proceeding and for no other purpose. Read our License Agreement for details. To license this animation for other purposes, click here.

If animation does not play, download and install the latest free Flash Player plugin.
More Like ThisAdd To Lightbox ANM10008 Enlarge Share
Ready to Purchase?

$999.00

Order by phone: (800) 338-5954
Item #ANM10008Source #1

Medication Distribution - Medical Animation
MEDICAL ANIMATION TRANSCRIPT:
Distribution is the process by which a medication is carried to its target tissue or site of action with the goal of causing a therapeutic response. This process follows medication absorption and precedes medication metabolism. Medication is first carried to highly vascularized tissues including the liver, heart, kidneys, and brain. Then medication is widely circulated within the body, reaching areas of less extensive blood supply such as skin, muscle, and fat. Medication then accumulates in the fat and in poorly vascularized tissues like bone, especially if the medication is lipophilic or strongly attracted to lipids. In the blood, some medication molecules bind to plasma proteins to which they are attracted. In this bound state, medication molecules are unable to produce a pharmacological effect. In bound and unbound form, the medication flows through the arteries and into capillaries. Capillaries carry the medication close to the tissue's cells, where hydrostatic pressure drives molecules between the capillary endothelial cells into the interstitial space. Some protein-bound macromolecules are too large to pass through the vessel walls, so they never reach the target tissue. Unbound or free molecules do reach the target tissue by exiting the bloodstream between the loss junctions in the capillary endothelium into the interstitial space to interact with the tissue cells. Some molecules bind to the cells while others remain in the extracellular fluid. The interaction of the unbound medication with the target tissue results in a therapeutic response. There are many factors that affect distribution. For example, the effect of membrane permeability on distribution can be demonstrated in the brain. The brain's capillaries are impermeable to the majority of medications due to the blood-brain barrier, a membrane that blocks the entrance of both toxic and therapeutic substances into brain tissues. Some medications penetrate the blood-brain barrier based on features like low polarity and high solubility in lipids. Fat-soluble molecules cross cell membranes faster than water-soluble molecules due to the lipophilic nature and phospholipid composition of the cellular membrane. Factors such as body fat percentage and disease also affect medication distribution. Fat deposits retain lipid-soluble unionized medication and release the molecules over time. Thus, obese patients may experience prolonged pharmacologic effects. Inflammation, disease, and injuries such as burns can alter protein levels and thus medication binding, increasing capillary permeability and uptake in cells and tissues. As a complication of kidney disease, albumin cannot bind medications effectively, resulting in a low percentage of protein-bound medication. These shifts result in high levels of free medications circulating throughout the body. ♪ [music] ♪

YOU MAY ALSO WANT TO REVIEW THESE ITEMS:
Post-accident Left Knee Injuries with Subsequent Surgical Repairs
Post-accident Left Knee Injuries with Subsequent Surgical Repairs - exh41644
Medical Exhibit
Add to my lightbox
Find More Like This
Blood Flow Through an Artery
Blood Flow Through an Artery - ANS00029
Medical Animation
Add to my lightbox
Find More Like This
Ulnar Nerve Decompression
Ulnar Nerve Decompression - BS00018
Medical Illustration
Add to my lightbox
Find More Like This
Right Elbow Fractures with Initial Surgical Fixation
Right Elbow Fractures with Initial Surgical Fixation - exh64849a
Medical Exhibit
Add to my lightbox
Find More Like This
Traumatic Head Injury
Traumatic Head Injury - exh75400c
Medical Exhibit
Add to my lightbox
Find More Like This
Pharmacodynamics - Pharmacokinectics
Pharmacodynamics - Pharmacokinectics - ANM11012
Medical Animation
Add to my lightbox
Find More Like This
What attorneys say about MLA and The Doe Report:
"There is nothing like a great graphic depicting the real nature and extent of a victim's injuries to get full value for your client. I use Medical Legal Art for mediations as well as trial."

Geoff Wells
Greene, Broillet, Panish & Wheeler
Santa Monica, CA

"At 3 PM it hit me--I needed exhibits of a tracheostomy, a coronary artery bypass and a deep vein thrombosis--all in time for a for-trial video deposition the next day. The Doe Report had each exhibit on line. In addition, I ran across an exhibit I hadn't even thought of: reduced ejection fraction after a heart attack. Because this was a video deposition, I could use the e-mail version of the medical exhibit, print it on my color copier, and let the camera zoom in. For $400, less than one blow-up by one of The Doe Report's competitors, I got four first-rate exhibits in less than a day. The Doe Report saved me time and money."

Tracy Kenyon Lischer
Pulley Watson King & Lischer
Durham, NC
www.PWKL.com

"You and your company are wonderful. Your service, turnaround time, quality and price were better than I could have asked for. Please add me to your long list of satisfied customers."

Robert F. Linton, Jr.
Linton & Hirshman
Cleveland, OH

"Our practice involves medical negligence cases exclusively. We have six attorneys and one physician on staff. We have used Medical Legal Art's staff for every one of our cases over the past 12 years and have found their services to be extraordinary. The transformation of medical records into powerful graphic images has without fail been handled expertly, expeditiously and effectively translating into superb results for our clients, both in the courtroom and in settlement. Every case can benefit from their excellent work and we unqualifiedly recommend their services. They are the best!"

Chris Otorowski
Morrow and Otorowski
Bainbridge Island, Washington
www.medilaw.com













Awards | Resources | Articles | Become an Affiliate | Free Medical Images | Pregnancy Videos
Credits | Jobs | Help | Medical Legal Blog | Find a Lawyer | Hospital Marketing