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Atherosclerosis - Medical Animation

 

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Atherosclerosis - Medical Animation
MEDICAL ANIMATION TRANSCRIPT: Atherosclerosis is a life-threatening disease that may have begun to develop during childhood. This condition is a process in which deposits of fatty material, called plaque, build up inside the walls of arteries, reducing or completely blocking blood flow. Although the exact causes of atherosclerosis are not clear, many scientists think it begins with damage to the inner wall of an artery, called the endothelium. Substances traveling in the blood, such as cholesterol, fats and cellular waste products, accumulate inside the damaged area of the arterial wall. Chemical reactions occurring within the buildup of material cause cholesterol molecules to oxidize. This initiates an inflammatory response in which the endothelial cells at the damage site release chemicals that signal a call for help. In response, monocytes from the bloodstream travel to the damage site. Stimulation from oxidized cholesterol converts the monocytes into macrophages. The macrophages eat and digest the cholesterol molecules. As a result of this process, the macrophages change into foam cells, which accumulate to form plaque. As the plaque increases in size, the arterial wall thickens and hardens. At the same time, smooth muscle cells within the arterial wall begin to multiply. Most of the smooth muscle cells move to the surface of the plaque. These cells contribute to the formation of a firm fibrous 'cap' covering the plaque. Eventually, the passageway through the artery narrows enough to reduce blood flow and the amount of oxygen received by the organs it supplies. Over time, the cap may erode and break open, releasing plaque into the bloodstream. The plaque can flow downstream and contribute to the formation of a blood clot, which can stop blood flow. As a result, limited blood supply is available to the areas surrounding the partially blocked artery, degrading and potentially killing the neighboring tissue.

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Brayton Purcell
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Davis Zipperman, Krischenbaum & Lotito
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"Medical illustrations are essential evidence in personal injury litigation and MLA is simply the best I've found at producing high-quality illustrations. Your illustrators are not only first-class artists, but creative and responsive. Your turn around time is as good as it gets. My clients have won over $60 million in jury verdicts and I can't recall a case which did not include one of your exhibits. On behalf of those clients, thanks and keep up the great work!"

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Valparaiso, IN
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"Thank you for the splendid medical-legal art work you did for us in the case of a young girl who was blinded by a bb pellet. As a result of your graphic illustrations of this tragic injury, we were able to persuade the insurance company to increase their initial offer of $75,000.00 to $475,000.00, just short of their policy limits.

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Coulter &Coulter
Roanoke, VA













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