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Atherosclerosis - Medical Animation

 

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Atherosclerosis - Medical Animation
MEDICAL ANIMATION TRANSCRIPT: Atherosclerosis is a life-threatening disease that may have begun to develop during childhood. This condition is a process in which deposits of fatty material, called plaque, build up inside the walls of arteries, reducing or completely blocking blood flow. Although the exact causes of atherosclerosis are not clear, many scientists think it begins with damage to the inner wall of an artery, called the endothelium. Substances traveling in the blood, such as cholesterol, fats and cellular waste products, accumulate inside the damaged area of the arterial wall. Chemical reactions occurring within the buildup of material cause cholesterol molecules to oxidize. This initiates an inflammatory response in which the endothelial cells at the damage site release chemicals that signal a call for help. In response, monocytes from the bloodstream travel to the damage site. Stimulation from oxidized cholesterol converts the monocytes into macrophages. The macrophages eat and digest the cholesterol molecules. As a result of this process, the macrophages change into foam cells, which accumulate to form plaque. As the plaque increases in size, the arterial wall thickens and hardens. At the same time, smooth muscle cells within the arterial wall begin to multiply. Most of the smooth muscle cells move to the surface of the plaque. These cells contribute to the formation of a firm fibrous 'cap' covering the plaque. Eventually, the passageway through the artery narrows enough to reduce blood flow and the amount of oxygen received by the organs it supplies. Over time, the cap may erode and break open, releasing plaque into the bloodstream. The plaque can flow downstream and contribute to the formation of a blood clot, which can stop blood flow. As a result, limited blood supply is available to the areas surrounding the partially blocked artery, degrading and potentially killing the neighboring tissue.

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"I wanted to take some time out to let you know what a wonderful job you did with the 'collapsed lung/fractured rib' illustrations. They were both detailed and accurate. My medical expert was comfortable working with them and he spent at least an hour explaining to the jury the anatomy of the lungs, the ribs and the injuries depicted in the illustrations. Needless to say, the jury was riveted to the doctor during his testimony.

The jury returned a verdict for $800,000.00 and I'm sure we would not have done so well if not for the visualizations we were able to put forth with your assistance. Lastly, my special thanks to Alice [Senior Medical Illustrator] who stayed late on Friday night and patiently dealt with my last minute revisions."

Daniel J. Costello
Proner & Proner
New York, NY

"Thank you very much for the great work on the medical exhibits. Our trial resulted in a $16 million verdict for a 9 year old boy with catastrophic injuries, and the medical illustrations definitely played key role in the trial."

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Brayton Purcell
Salt Lake City, UT

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White Rock, British Columbia
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Kenneth Allen & Associates
Valparaiso, IN













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